Four people have died after a minivan with nine occupants crashed in regional Victoria

The van was driving on Chapel Road in Muckatah, about 250 kilometres north of Melbourne, when the driver lost control and crashed into a tree at about 5pm yesterday.

Four passengers, who are yet to be formally identified, died at the scene.

Two children are fighting for life, whilst the driver was seriously injured. (Nine)

Three children between the ages of 10 and 16 were airlifted to hospital, with two of them believed to be suffering from life-threatening injuries.

The driver and another passenger were taken to hospital in Melbourne via road, also with serious injuries.

Locals claim the stretch of road is a dangerous one. (Nine)

Police suspect the people involved in the crash were fruit pickers local to the area, though this has yet to be confirmed.

The exact circumstances surrounding the crash are yet to be determined.

Locals said the stretch of road where the accident occurred can be dangerous.

Ambulance Victoria said three air ambulances as well as Mobile Intensive Care Ambulance and Advanced Life Support paramedics were sent to the scene.

Anyone with information or dashcam footage is urged to contact Crime Stoppers 1800 333 000.