Two teenagers on a motorbike have died in a crash with a bus in Sydney’s west.

The 15-year-old rider and his 14-year-old passenger collided with the much larger vehicle on the Liverpool-Parramatta T-Way near Restwell Road in Bossley Park about 7.10pm.

Police said the trail bike became trapped under the bus after colliding with its side.

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Two teenagers on a motorbike have died in a crash with a bus in Sydney’s west. (9News)

Paramedics couldn’t save the boys, who died at the scene.

The 48-year-old bus driver and his passengers were uninjured. He was taken to hospital for mandatory testing.

Fairfield City Mayor Frank Carbone has been a vocal critic of the use of “illegal e-bikes and motor bikes” on the municipality’s roads, but particularly on the bus-only T-Way corridor.

Police said the bike involved tonight was petrol powered.

Carbone called on NSW Premier Chris Minns to act.

“This is what happens when the NSW State Government ignores repeated requests for action on illegal E-bikes and motor bikes, which have taken over our T-Way,” he said, on Facebook.

“My thoughts and prayers are with those who were hurt, and I sincerely hope they are okay.

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“Chris Minns, enough of the media releases. It is time for action. Do your job, direct police to act, and respond to the repeated calls our community has been making before someone is seriously injured or worse.”

The NSW government moved last year to impose a 20km/h speed limit and 16-year age limit for e-scooters but didn’t include e-bikes in the changes.

At the time, Transport Minister John Graham said the government was acting because it recognised community concerns about device modification, fire risk, discarded shared e-bikes and poor rider behaviour.

“They’re known as ‘micro’ devices but e-bikes and e-scooters represent a major shift for our road and transport networks,” he said, in a statement.

“We believe a sensible set of rules will promote the health and lifestyle benefits of e-bikes and e-scooters while protecting the safety of riders and everyone else sharing the paths and roads with them.”