First-Look Video Released for Fox’s ‘Best Medicine’: Josh Charles Leads ‘Doc Martin’ Remake with Star-Studded Cast
By Grok News Desk December 13, 2025
Fox has unveiled a captivating first-look video for its upcoming comedy-drama Best Medicine, the highly anticipated American remake of the beloved British series Doc Martin, showcasing Emmy nominee Josh Charles in the lead role and hinting at deeper emotional layers beneath the quirky surface.
The series follows Dr. Martin Best (Charles), a highly skilled but socially abrasive surgeon who suddenly abandons his prestigious Boston practice to take over as general practitioner in a picturesque East Coast fishing village—the same idyllic spot where he spent childhood summers with his Aunt Sarah (Annie Potts). His no-nonsense, often rude bedside manner immediately grates on the eccentric locals, who desperately need a doctor but struggle with his bluntness.
Key townsfolk include charming schoolteacher Louisa Gavin (Abigail Spencer), who clashes yet connects with Best; affable Sheriff Mark Mylow (Josh Segarra); and Best’s well-meaning but clumsy assistant Elaine Denton (Cree). The ensemble promises rich interpersonal dynamics, blending humor with heartfelt moments.
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The video emphasizes Best’s desire for solitude—”desperate to be left the hell alone”—only to find himself entangled in the community’s feuds, fantasies, and personal dramas. Despite his diagnostic brilliance, Best’s terse demeanor hides “A DEBILITATING NEW PHOBIA AND DEEP-SEATED PSYCHOLOGICAL ISSUES THAT PREVENT HIM FROM EXPERIENCING TRUE INTIMACY WITH ANYONE.” Trailers tease childhood trauma and a secret vulnerability, adding mystery to his abrupt career shift.
Locals’ tenacity shines through, with the synopsis noting: “The people who live there may be exactly what the doctor ordered.” Original Doc Martin star Martin Clunes guests as Best’s estranged father, heightening family tensions.
Produced by Fox Entertainment Studios, Best Medicine is adapted by Liz Tuccillo with executive producers including Ben Silverman and original Doc Martin creators Mark Crowdy and Philippa Braithwaite. Filming occurred in upstate New York, capturing authentic small-town charm.
Supporting cast includes recurring players like Didi Conn, Clea Lewis, and a canine companion, Wattson, adding whimsical touches.
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Early buzz praises the trailer’s blend of wit, warmth, and intrigue, positioning the show as a fresh one-hour comedy for Fox’s lineup. Fans of the original appreciate faithful nods while welcoming American twists.
Best Medicine receives a special preview debut Sunday, January 4, 2026, at 8 p.m. following an NFL doubleheader, before settling into Tuesdays at 8 p.m. starting January 6.
With Charles’ nuanced performance and a talented ensemble, the series promises to heal broadcast TV’s comedy gap—one quirky diagnosis at a time.
